A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
Treatment Strategies and Perforation Rate of Acute Appendicitis During the Early Phase of the Covid-19 Pandemic: A Swedish Cohort StudyResearch article Published on 2022-12-012022-10-05 Journal: The Journal of surgical research [Category] 치료법, [키워드] 95% confidence interval Acute appendicitis Appendicitis association calculate Care Conservative management COVID-19 COVID-19 pandemic diagnosed early phase Frequency initial less multivariate logistic regression Odds ratio pandemic Patient patients hospitalized Perforation Perforation rate phase Rate receive resource Result risk severity single-center study South Strategy surgical Swedish Treatment Treatment strategies [DOI] 10.1016/j.jss.2022.07.007 [Article Type] Research article
Clinical course of patients with chronic limb-threatening ischemia developing COVID-19Article Published on 2022-12-012022-11-16 Journal: Journal of cardiology [Category] 변종, [키워드] 30-Day mortality 95 % CI acute respiratory syndrome added Analysis association calculated Cardiovascular events caused chronic Chronic limb-threatening ischemia claudication clinical Clinical course confidence interval control group coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patient Cox regression analysis demonstrated diagnosis of COVID-19 disease evaluate the effect hazard ratio Healthcare systems high risk increased risk initial IPW Ischemia Japan Mortality mortality risk omicron omicron variant. pandemic Patient patients patients with COVID-19 primary outcome measure Probability proportion reached Regression model reported significantly higher treated Treatment variant was used Weighting [DOI] 10.1016/j.jjcc.2022.07.010 PMC 바로가기
Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections예방접종을 받지 않은 입원 소아에서 SARS-CoV-2 Omicron BA.2 감염의 심각도: 인플루엔자 및 파라인플루엔자 감염과의 비교Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Admission children Clinical outcome coronavirus COVID-19 COVID-19 infection Croup database death had no hospitalisation hospitalisations Hospitalization Hospitalized Infection Influenza Influenza virus initial investigated Mild neurological Neurological complication Neurological complications occurred omicron outcome parainfluenza parainfluenza virus proportion Public Hospital Relative risk required respiratory. retrieved risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity uninfected upper airway upper airways vaccination variant viral infections virus viruses were recorded [DOI] 10.1080/22221751.2022.2093135 PMC 바로가기 [Article Type] Article
Mapping post-traumatic stress disorder symptoms and quality of life among residents of Wuhan, China after the COVID-19 outbreak: A network perspectiveResearch article Published on 2022-12-012022-10-05 Journal: Journal of affective disorders [Category] 진단, [키워드] approach Attention changes in checklist Chinese Civilian Community conducted connection covariates COVID-19 COVID-19 outbreak cross-sectional cross-sectional survey emotional examined Follow-up General population initial lack life limitation mapping mental health network analysis objective outbreak pandemic participant Perspective Post-traumatic stress disorder Post-traumatic stress disorder symptoms Quality Quality of life Result self-report measure Study design Symptom Version were measured World Health Organization Wuhan Wuhan residents Wuhan, China [DOI] 10.1016/j.jad.2022.08.074 [Article Type] Research article
Inflammatory bowel disease patient concerns and experiences on transition to home-based infusions during the COVID-19 pandemicArticle Published on 2022-12-012022-11-15 Journal: Research in social & administrative pharmacy : RSA [Category] 진단, [키워드] adverse event age analyzed approach biologics bowel Care category CDC Characteristics collected conducted COVID-19 COVID-19 pandemic COVID-19 transmission disease Factor Guidance Inflammatory bowel disease Infusions. initial iterative one patient outcome pandemic participant Patient performed persistence positive resolved social distancing transitioned [DOI] 10.1016/j.sapharm.2022.06.009 PMC 바로가기
Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associationsArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Abstract affecting articles association biological processe Cell comprehensive resource COVID-19 criteria curated database dataset develop diabetes differentially expressed gene dysregulated enriched biological processes environmental factor environmental factors Gene Expression Gene Expression Omnibus Genes Infection initial Interaction lung cancer pathway predict R package retrieved rheumatoid arthritis selected signature smoking statistical analysis statistically tested [DOI] 10.1038/s41598-022-21988-6 PMC 바로가기
A Chatbot to Support Young People During the COVID-19 Pandemic in New Zealand: Evaluation of the Real-World Rollout of an Open TrialArticle Published on 2022-11-042022-11-15 Journal: Journal of Medical Internet Research [Category] 치료제, [키워드] Adolescent mental health age Anxiety chatbot chatbots cognitive commenced Community connection COVID-19 detect dialog-based intervention digital mental health feasibility feedback flexible help highlight implementation initial iterative lockdown maintain management Mental mental health New online questionnaire open trial Positive psychology Support therapy trial infrastructure youth. [DOI] 10.2196/38743 PMC 바로가기
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기